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  夏偉梁

  夏偉梁，意昂4平台長聘正教授，博士生導師，致遠意昂4副院長, 腫瘤系統醫學全國重點實驗室兼職課題組長。曾於清華大學、香港大學🐎🐾、美國洛克菲勒大學及加州大學舊金山分校學習和深造。入選上海市科委啟明星、上海交大晨星學者🤦🏽‍♀️🦁、唐立新優秀學者😴，獲教育部“基礎學科拔尖學生培養計劃2.0”榮譽獎項-優秀管理人員獎、中華醫學科技獎二等獎🏃、意昂4平台教書育人集體獎二等獎及教學成果獎特等獎等榮譽ℹ️。任中國生物醫學工程學會🍅、中國細胞生物學學會😤、美國癌症研究協會會員；Extracellular Vesicles and Circulating Nucleic Acids(EVCNA) 副主編👐，Frontiers in Oncology-Molecular and Cellular Oncology， Associate Editor。曾任中國細胞生物學學會第二屆青年工作委員會委員🤹🏿‍♂️、意昂4平台學術委員會委員（2016-2020年）。

   

  立足醫工交叉，聚焦肺癌等難治疾病的機製和診療新靶點，研究FGF/FGFR等生長因子信號促進肺癌進展和外泌體生物學及診療應用🛵。主持科技部973課題🤸、國家自然科學基金委🧑🏿‍🚀、醫工交叉重點等基金十余項。在Science Translational Medicine, Cell Death & Differentiation🕴👷🏼、PNAS💆🏼‍♂️、Oncogene、Protein Cell、 Biomaterials等發表約130余篇學術論文👨🏿‍🚒，H-因子50。

腫瘤進展👃🏻、治療抵抗的機製及新靶點發現（Mechanisms of lung/prostate cancer progression and treatment resistance, and discovery of novel targets）; 外泌體生物學及其應用（biology of exosome and applications）; FGF/FGFR和Sirtuin在腫瘤和組織修復的作用（role of FGF/FGFR and sirtuin in cancer and tissue repair）🏃🏻‍♀️‍➡️。

1.       Chen Z, Ji W, Feng W, Cui J, Wang Y, Li F, Chen J, Guo Z, Xia L, Zhu X, Niu X, Zhang Y, Li Z, Wong AS, Lu S*, Xia W*. PTPRT loss enhances anti-PD-1 therapy efficacy by regulation of STING pathway in non-small cell lung cancer. Sci Transl Med. 2024 Sep 4;16(763):eadl3598. doi: 10.1126/scitranslmed.adl3598.

2.       Wu T, Zhang Y, Han Q, Lu X, Cheng Y, Chen J, Sha J, Xia W*. Klotho-beta attenuates Rab8a-mediated exosome regulation and promotes prostate cancer progression. Oncogene. 2023;42:2801-2815.

3.       Zhang Y, Wu T, Wang Y, Chen Z, Chen J, Lu S, Xia W*. Reciprocal FGF19-GLI2 signaling induces epithelial-to-mesenchymal transition to promote lung squamous cell carcinoma metastasis. Cell Oncol. 2023;46:437-450.

4.       Tian A, Wu T, Zhang Y, Chen J, Sha J, Xia W*. Triggering pyroptosis enhances the antitumor efficacy of PARP inhibitors in prostate cancer. Cell Oncol. 2023;46:1855-1870.

5.       Lu X, Han Q, Chen J, Wu T, Cheng Y, Li F, Xia W*. Celery (Apium graveolens L.) Exosome-like Nanovesicles as a New-Generation Chemotherapy Drug Delivery Platform against Tumor Proliferation. J Agri Food Chem. 2023; 71:8413-8424.

6.       Cheng Y, Lu X, Li F, Chen Z, Zhang Y, Han Q, Zeng Q, Wu T, Li Z, Lu S, Williams C, Xia W*. NDFIP1 limits cellular TAZ accumulation via exosomal sorting to inhibit NSCLC proliferation. Protein Cell. 2023;14:123-136.

7.       Han Q, Xie QR, Li F, Cheng Y, Wu T, Zhang Y, Lu X, Wong AST, Sha J*, Xia W*. Targeted inhibition of SIRT6 via engineered exosomes impairs tumorigenesis and metastasis in prostate cancer. Theranostics. 2021;11:6526-6541.

8.       Yang X, Zhang Y, Geng K, Yang K, Shao J, Xia W*. Sirt3 protects against ischemic stroke injury by regulating HIF-1α/VEGF signaling and blood–brain barrier integrity. Cell Mol Neurobiol. 2021;41: 1203-1215.

9.       Li F, Li Z, Han Q, Chen Y, Ji W, Yang Y, Lu S, Xia W*. Enhanced autocrine FGF19/FGFR4 signaling drives the progression of lung squamous cell carcinoma, which responds to mTOR inhibitor AZD2104. Oncogene. 2020; 37:3507–3521.

10.    Cheng Y, Zeng Q, Han Q, Xia W*. Effect of pH, temperature and freezing-thawing on quantity changes and cellular uptake of exosomes. Protein Cell. 2019; 10:295-299.

11.    Liu J, Liu Y, Shao J, Li Y, Qin L, Shen H, Xie Y, Xia W*, Gao WQ*. Zeb1 is important for proper cleavage plane orientation of dividing progenitors and neuronal migration in the mouse neocortex. Cell Death Differ.2019; 26:2479-2492.

12.    Lu T, Li Z, Yang Y, Ji W, Yu Y, Niu X, Zeng Q, Xia W*, Lu S*. The Hippo/YAP1 pathway interacts with FGFR1 signaling to maintain stemness in lung cancer. Cancer Lett. 2018; 423:36-46.

13.    Wang K, Ji W, Yu Y, Li Z, Niu X, Xia W*, Lu S*. FGFR1-ERK1/2-SOX2 axis promotes cell proliferation, epithelial-mesenchymal transition, and metastasis in FGFR1-amplified lung cancer. Oncogene. 2018; 37:5340-5354.

14.    Shao J, Yang X, Liu T, Zhang T, Xie QR, Xia W*. Autophagy induction by SIRT6 is involved in oxidative stress-induced neuronal cell death. Protein Cell. 2016, 7:281-290. 

15.    Chen Y, Gu H*, Zhang DS, Li F, Liu T, Xia W*.Highly effective inhibition of lung cancer growth and metastasis by systemic delivery of siRNA via multimodal mesoporous silica-based nanocarrier. Biomaterials. 2014;35:10058-10069.

16.    Xie QR, Liu Y, Shao J, Yang J, Liu T, Zhang T, Wang B, Mruk DD, Silvestrini B, Cheng CY, Xia W*. Male contraceptive Adjudin is a potential anti-cancer drug.  Biochem Pharmacol 2013; 85:345-355.