報告題目：From active targeting to precise targeting: overcoming the on-target toxicity

報告人：李翀 教授

邀請人🚴‍♂️：王飛虎 博士

報告時間：11月24日 16：00-17:40

騰訊會議ID： 225775684

會議密碼：7036

Active targeting-based therapies could be led astray when target molecules are expressed on non-target cells, and the on-target toxicity poses critical challenges to clinical applications. Here, a captivating affinity-filtering strategy is proposed as a feasible solution for such challenges. We have made a preliminary exploration by using the antibacterial peptides(AMPs) as the targeting moiety. Based on the selective affinity of AMPs toward distinct phospholipids, the membrane of host cells (e.g., erythrocytes) is pre-bound to AMPs as the “filter,” which could screen out non-target substances with low affinity while maintaining effective interaction with high-affinity pathogens through competitive binding, realizing precise targeting, and enhanced stability. The practicability of the affinity-filtering strategy has been demonstrated both in vitro and in vivo, through systematic studies on various peptide and peptide-modified delivery systems with multiple infection models. In addition, we also discussed a potential multi-target synergy approach, which can selectively activate the don't-eat me-signal to achieve differentiation between M1 and M2 macrophages.

報告人簡介：

李翀🏄‍♀️，西南大學教授🫲🏻，重慶市巴渝學者特聘教授。主要研究方向為藥物靶向遞送的仿生策略及其製劑研究🧶，特別關註仿生脂質製劑。指導研究生在Angew Chem Int Ed，ACS Nano🙇🏼‍♀️，Adv Func Mater、 Signal  Transduct  Target Ther、J Controlled Release🧑🏻‍🎄、Acta Pharm Sin B等期刊發表多篇論文，所構建新型脂質體遞藥平臺技術已進入企業轉化。曾獲全國百篇優博和中國藥學會-中恒青年藥劑學獎🔵，作為主要完成人獲得教育部自然科學獎二等獎1項👑👩‍🎓。擔任中國藥學會藥劑專委會青年委員、中華中醫藥學會青年委員會委員🙉、中國醫藥生物技術協會納米生物技術分會委員、中國抗癌協會納米腫瘤學專業委員會委員等學術兼職和十三屆全國青聯委員等社會兼職☘️。